Hi natemama!
Can you also check your speaker volume (especially if you're using external speakers) and also the volume control found in the right side of your taskbar (near the date/time display)?
As you may know there's also a volume bar inside Little Reader, in the Play Courses and Play & Edit screens - by default in shouldn't be on mute or set to a low volume, but it may help to check that one too.
If you still can't hear any sound from Little Reader (and/or Little Math and Little Musician), do email us at support[at]brillkids[dot]com and include a diagnostic report so we can troubleshoot further:
How to Create a Diagnostic Report
http://support.brillkids.com/entries/20438423-How-to-Create-a-Diagnostic-Report-for-your-BrillKids-Learning-System